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LRRK2 and the Endolysosomal System in Parkinson’s Disease

Mutations in leucine-rich repeat kinase 2 (LRRK2) cause autosomal dominant familial Parkinson’s disease (PD), with pathogenic mutations enhancing LRRK2 kinase activity. There is a growing body of evidence indicating that LRRK2 contributes to neuronal damage and pathology both in familial and sporadi...

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Bibliografiske detaljer
Udgivet i:J Parkinsons Dis
Main Authors: Erb, Madalynn L., Moore, Darren J.
Format: Artigo
Sprog:Inglês
Udgivet: IOS Press 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7677880/
https://ncbi.nlm.nih.gov/pubmed/33044192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JPD-202138
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