LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson’s disease

LRRK2 has been implicated in endolysosomal function and likely plays a central role in idiopathic Parkinson’s disease (iPD). In iPD, dopaminergic neurons within the substantia nigra are characterized by increased LRRK2 kinase activity, endolysosomal deficits, and accumulation of autophagic vesicles...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Neurobiol Dis
Autors principals: Rocha, Emily M., De Miranda, Briana R., Castro, Sandra, Drolet, Robert, Hatcher, Nathan G., Yao, Lihang, Smith, Sean M., Keeney, Matthew T., Di Maio, Roberto, Kofler, Julia, Hastings, Teresa G., Greenamyre, J. Timothy
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7345850/
https://ncbi.nlm.nih.gov/pubmed/31618685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2019.104626
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars