LRRK2 inhibition prevents endolysosomal deficits seen in human Parkinson’s disease

LRRK2 has been implicated in endolysosomal function and likely plays a central role in idiopathic Parkinson’s disease (iPD). In iPD, dopaminergic neurons within the substantia nigra are characterized by increased LRRK2 kinase activity, endolysosomal deficits, and accumulation of autophagic vesicles...

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Bibliographic Details
Published in:Neurobiol Dis
Main Authors: Rocha, Emily M., De Miranda, Briana R., Castro, Sandra, Drolet, Robert, Hatcher, Nathan G., Yao, Lihang, Smith, Sean M., Keeney, Matthew T., Di Maio, Roberto, Kofler, Julia, Hastings, Teresa G., Greenamyre, J. Timothy
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7345850/
https://ncbi.nlm.nih.gov/pubmed/31618685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2019.104626
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