The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson’s disease

Gene-environment interaction is implicated in the majority of idiopathic Parkinson’s disease (PD) risk, and some of the most widespread environmental contaminants are selectively toxic to dopaminergic neurons. Pesticides have long been connected to PD incidence, however, it has become increasingly a...

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Pubblicato in:Neurobiol Dis
Autori principali: De Miranda, Briana R., Castro, Sandra L., Rocha, Emily M., Bodle, Christopher R., Johnson, Katrina E., Greenamyre, J. Timothy
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8026730/
https://ncbi.nlm.nih.gov/pubmed/33636387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2021.105312
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