Negative regulation of mitochondrial transcription by mitochondrial topoisomerase I

Mitochondrial topoisomerase I is a genetically distinct mitochondria-dedicated enzyme with a crucial but so far unknown role in the homeostasis of mitochondrial DNA metabolism. Here, we present data suggesting a negative regulatory function in mitochondrial transcription or transcript stability. Def...

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Hauptverfasser: Sobek, Stefan, Dalla Rosa, Ilaria, Pommier, Yves, Bornholz, Beatrice, Kalfalah, Faiza, Zhang, Hongliang, Wiesner, Rudolf J., von Kleist-Retzow, Jürgen-Christoph, Hillebrand, Frank, Schaal, Heiner, Mielke, Christian, Christensen, Morten O., Boege, Fritz
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2013
Schlagworte:
Nucleic Acid Enzymes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834834/
https://ncbi.nlm.nih.gov/pubmed/23982517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt768
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