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Cytochrome P4503A Does Not Mediate the Interaction between Methadone and Ritonavir-Lopinavir
Plasma concentrations of orally administered methadone are reduced by the human immunodeficiency virus protease inhibitor combination ritonavir and lopinavir, but the mechanism is unknown. Methadone metabolism, clearance, and drug interactions have been attributed to CYP3A4, but this remains controv...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The American Society for Pharmacology and Experimental Therapeutics
2013
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3834136/ https://ncbi.nlm.nih.gov/pubmed/24067429 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.053991 |
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