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Interaction of human cytochrome P4503A4 with ritonavir analogs
Ritonavir is a HIV protease inhibitor that also potently inactivates cytochrome P450 3A4 (CYP3A4), a major human drug-metabolizing enzyme. To better understand the mechanism of ligand binding and to find strategies for improvement of the inhibitory potency of ritonavir, currently administered to enh...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3606017/ https://ncbi.nlm.nih.gov/pubmed/22410611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2012.02.018 |
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