Loading...
Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activity
BACKGROUND: Methadone plasma concentrations are decreased by nelfinavir. Methadone clearance and the drug interactions have been attributed to CYP3A4, but actual mechanisms of methadone clearance and the nelfinavir interaction are unknown. We assessed nelfinavir effects on methadone pharmacokinetics...
Na minha lista:
| Main Authors: | , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
|
| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3582041/ https://ncbi.nlm.nih.gov/pubmed/19232844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drugalcdep.2008.12.009 |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|