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Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activity

BACKGROUND: Methadone plasma concentrations are decreased by nelfinavir. Methadone clearance and the drug interactions have been attributed to CYP3A4, but actual mechanisms of methadone clearance and the nelfinavir interaction are unknown. We assessed nelfinavir effects on methadone pharmacokinetics...

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Bibliografiske detaljer
Main Authors: Kharasch, Evan D., Walker, Alysa, Whittington, Dale, Hoffer, Christine, Bedynek, Pamela Sheffels
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582041/
https://ncbi.nlm.nih.gov/pubmed/19232844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drugalcdep.2008.12.009
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