Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics. II. Ritonavir effects on CYP3A and P-glycoprotein activities

Ritonavir diminishes methadone plasma concentrations, attributed to CYP3A, but mechanisms are unknown. We determined short-term (2 day) and steady-state (2 week) ritonavir effects on intestinal/hepatic CYP3A (probed with IV and oral alfentanil, and miosis), P-glycoprotein (fexofenadine) and methadon...

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Bibliographic Details
Main Authors: Kharasch, Evan D., Bedynek, Pamela Sheffels, Walker, Alysa, Whittington, Dale, Hoffer, Christine, Park, Sang
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3583338/
https://ncbi.nlm.nih.gov/pubmed/19238656
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