Mechanism of efavirenz influence on methadone pharmacokinetics and pharmacodynamics II: Hepatic and intestinal CYP2B6, CYP3A and transporter activities

Efavirenz diminishes methadone plasma concentrations, an effect attributed to CYP3A induction, but actual mechanisms are unknown. This investigation determined the effects of two weeks of efavirenz (600 mg daily) on hepatic and intestinal CYP3A4/5 (probed with intravenous and oral alfentanil), hepat...

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Bibliografiske detaljer
Main Authors: Kharasch, Evan D., Campbell, Scott, Stubbert, Kristi, Crafford, Amanda, London, Amy, Kim, Thomas, Whittington, Dale, Ensign, Dustin, Hoffer, Christine, Bedynek, Pamela Sheffels
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600645/
https://ncbi.nlm.nih.gov/pubmed/22398970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2011.276
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