Mechanism of efavirenz influence on methadone pharmacokinetics and pharmacodynamics II: Hepatic and intestinal CYP2B6, CYP3A and transporter activities

Efavirenz diminishes methadone plasma concentrations, an effect attributed to CYP3A induction, but actual mechanisms are unknown. This investigation determined the effects of two weeks of efavirenz (600 mg daily) on hepatic and intestinal CYP3A4/5 (probed with intravenous and oral alfentanil), hepat...

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Main Authors: Kharasch, Evan D., Campbell, Scott, Stubbert, Kristi, Crafford, Amanda, London, Amy, Kim, Thomas, Whittington, Dale, Ensign, Dustin, Hoffer, Christine, Bedynek, Pamela Sheffels
格式: Artigo
語言:Inglês
出版: 2012
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3600645/
https://ncbi.nlm.nih.gov/pubmed/22398970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2011.276
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