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Cytochrome P4503A Does Not Mediate the Interaction between Methadone and Ritonavir-Lopinavir

Plasma concentrations of orally administered methadone are reduced by the human immunodeficiency virus protease inhibitor combination ritonavir and lopinavir, but the mechanism is unknown. Methadone metabolism, clearance, and drug interactions have been attributed to CYP3A4, but this remains controv...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Kharasch, Evan D., Stubbert, Kristi
פורמט: Artigo
שפה:Inglês
יצא לאור: The American Society for Pharmacology and Experimental Therapeutics 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834136/
https://ncbi.nlm.nih.gov/pubmed/24067429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.053991
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