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Role of cytochrome P4502B6 in methadone metabolism and clearance
Methadone N-demethylation in vitro is catalyzed by hepatic cytochrome P4502B6 (CYP2B6) and CYP3A4, but clinical disposition is often attributed to CYP3A4. This investigation tested the hypothesis that CYP2B6 is a prominent CYP isoform responsible for clinical methadone N-demethylation and clearance,...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3743098/ https://ncbi.nlm.nih.gov/pubmed/23361846 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1 |
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