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Role of cytochrome P4502B6 in methadone metabolism and clearance

Methadone N-demethylation in vitro is catalyzed by hepatic cytochrome P4502B6 (CYP2B6) and CYP3A4, but clinical disposition is often attributed to CYP3A4. This investigation tested the hypothesis that CYP2B6 is a prominent CYP isoform responsible for clinical methadone N-demethylation and clearance,...

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Библиографические подробности
Главные авторы: Kharasch, Evan D., Stubbert, Kristi
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3743098/
https://ncbi.nlm.nih.gov/pubmed/23361846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1
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