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Rapid Clinical Induction of Hepatic Cytochrome P4502B6 Activity by Ritonavir
Ritonavir is the most potent and efficacious inhibitor of cytochrome P4503A (CYP3A), and it is used accordingly for the pharmacoenhancement of other antiretrovirals. Paradoxically, ritonavir induces the clinical metabolism and clearance of many drugs. The mechanism by which ritonavir inhibits and in...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2346649/ https://ncbi.nlm.nih.gov/pubmed/18285471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01600-07 |
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