Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice

PC7 belongs to the proprotein convertase family, whose members are implicated in the cleavage of secretory precursors. The in vivo function of PC7 is unknown. Herein, we find that the precursor proBDNF is processed into mature BDNF in COS-1 cells coexpressing proBDNF with either PC7 or Furin. Conver...

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Detalhes bibliográficos
Main Authors: Wetsel, William C., Rodriguiz, Ramona M., Guillemot, Johann, Rousselet, Estelle, Essalmani, Rachid, Kim, Il Hwan, Bryant, Jesse C., Marcinkiewicz, Jadwiga, Desjardins, Roxane, Day, Robert, Constam, Daniel B., Prat, Annik, Seidah, Nabil G.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808632/
https://ncbi.nlm.nih.gov/pubmed/24101515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1314698110
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