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Is there a link between proprotein convertase PC7 activity and human lipid homeostasis?

A genome-wide association study suggested that a R504H mutation in the proprotein convertase PC7 is associated with increased circulating levels of HDL and reduced triglycerides in black Africans. Our present results show that PC7 and PC7-R504H exhibit similar processing of transferrin receptor-1, p...

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Détails bibliographiques
Auteurs principaux: Guillemot, Johann, Essalmani, Rachid, Hamelin, Josée, Seidah, Nabil G.
Format: Artigo
Langue:Inglês
Publié: Elsevier 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4208093/
https://ncbi.nlm.nih.gov/pubmed/25349778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.fob.2014.08.004
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