Rapamycin inhibition of mTORC1 reverses lithium-induced proliferation of renal collecting duct cells

Nephrogenic diabetes insipidus (NDI) is the most common renal side effect in patients undergoing lithium therapy for bipolar affective disorders. Approximately 2 million US patients take lithium of whom ∼50% will have altered renal function and develop NDI (2, 37). Lithium-induced NDI is a defect in...

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Main Authors: Gao, Yang, Romero-Aleshire, Melissa J., Cai, Qi, Price, Theodore J., Brooks, Heddwen L.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2013
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798728/
https://ncbi.nlm.nih.gov/pubmed/23884148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00153.2013
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