Presenilin-1/γ-Secretase Controls Glutamate Release, Tyrosine Phosphorylation, and Surface Expression of N-Methyl-d-aspartate Receptor (NMDAR) Subunit GluN2B

Abnormally high concentrations of extracellular glutamate in the brain may cause neuronal damage via excitotoxicity. Thus, tight regulation of glutamate release is critical to neuronal function and survival. Excitotoxicity is caused mainly by overactivation of the extrasynaptic NMDA receptor (NMDAR)...

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Detalhes bibliográficos
Main Authors: Xuan, Zhao, Barthet, Gael, Shioi, Junichi, Xu, Jindong, Georgakopoulos, Anastasios, Bruban, Julien, Robakis, Nikolaos K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3798513/
https://ncbi.nlm.nih.gov/pubmed/24025330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.499004
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