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Diminished origin licensing capacity specifically sensitises tumour cells to replication stress

Previous studies have shown that dormant licensed replication origins can be exploited to enhance recovery from replication stress. Since tumour cells express high levels of origin licensing proteins, we examined whether depletion of such factors might specifically sensitise tumour versus non-tumour...

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Detalhes bibliográficos
Main Authors: Zimmerman, Kristin M., Jones, Rebecca M., Petermann, Eva, Jeggo, Penelope A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3797919/
https://ncbi.nlm.nih.gov/pubmed/23364533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-12-0491
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