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Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress
T-LAK-originated protein kinase (TOPK) overexpression is a feature of multiple cancers, yet is absent from most phenotypically normal tissues. As such, TOPK expression profiling and the development of TOPK-targeting pharmaceutical agents have raised hopes for its future potential in the development...
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| Pubblicato in: | Cell Death Differ |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8027845/ https://ncbi.nlm.nih.gov/pubmed/33168956 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-00655-1 |
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