TOPK modulates tumour-specific radiosensitivity and correlates with recurrence after prostate radiotherapy

BACKGROUND: Tumour-specific radiosensitising treatments may enhance the efficacy of radiotherapy without exacerbating side effects. In this study we determined the radiation response following depletion or inhibition of TOPK, a mitogen-activated protein kinase kinase family Ser/Thr protein kinase th...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Pirovano, Giacomo, Ashton, Thomas M, Herbert, Katharine J, Bryant, Richard J, Verrill, Clare L, Cerundolo, Lucia, Buffa, Francesca M, Prevo, Remko, Harrap, Iona, Ryan, Anderson J, Macaulay, Valentine, McKenna, William G, Higgins, Geoff S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5558685/
https://ncbi.nlm.nih.gov/pubmed/28677687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2017.197
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