The anti-malarial drug atovaquone potentiates platinum-mediated cancer cell death by increasing oxidative stress

Platinum chemotherapies are highly effective cytotoxic agents but often induce resistance when used as monotherapies. Combinatorial strategies limit this risk and provide effective treatment options for many cancers. Here, we repurpose atovaquone (ATQ), a well-tolerated & FDA-approved anti-malar...

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Detalhes bibliográficos
Publicado no:Cell Death Discov
Main Authors: Coates, James T. T., Rodriguez-Berriguete, Gonzalo, Puliyadi, Rathi, Ashton, Thomas, Prevo, Remko, Wing, Archie, Granata, Giovanna, Pirovano, Giacomo, McKenna, Gillies W., Higgins, Geoff S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7591508/
https://ncbi.nlm.nih.gov/pubmed/33133645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-020-00343-6
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