Excess Mcm2–7 license dormant origins of replication that can be used under conditions of replicative stress

In late mitosis and early G1, replication origins are licensed for subsequent use by loading complexes of the minichromosome maintenance proteins 2–7 (Mcm2–7). The number of Mcm2–7 complexes loaded onto DNA greatly exceeds the number of replication origins used during S phase, but the function of th...

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Detalhes bibliográficos
Main Authors: Woodward, Anna M., Göhler, Thomas, Luciani, M. Gloria, Oehlmann, Maren, Ge, Xinquan, Gartner, Anton, Jackson, Dean A., Blow, J. Julian
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2006
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063885/
https://ncbi.nlm.nih.gov/pubmed/16754955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200602108
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