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Dormant Origins, the Licensing Checkpoint, and the Response to Replicative Stresses

Only ∼10% of replication origins that are licensed by loading minichromosome maintenance 2-7 (MCM2-7) complexes are normally used, with the majority remaining dormant. If replication fork progression is inhibited, nearby dormant origins initiate to ensure that all of the chromosomal DNA is replicate...

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Autors principals: McIntosh, Debbie, Blow, J. Julian
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475168/
https://ncbi.nlm.nih.gov/pubmed/22904560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a012955
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