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Dormant Origins, the Licensing Checkpoint, and the Response to Replicative Stresses

Only ∼10% of replication origins that are licensed by loading minichromosome maintenance 2-7 (MCM2-7) complexes are normally used, with the majority remaining dormant. If replication fork progression is inhibited, nearby dormant origins initiate to ensure that all of the chromosomal DNA is replicate...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: McIntosh, Debbie, Blow, J. Julian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2012
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3475168/
https://ncbi.nlm.nih.gov/pubmed/22904560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a012955
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