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Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication

The six main minichromosome maintenance proteins (Mcm2–7), which presumably constitute the core of the replicative DNA helicase, are present in chromatin in large excess relative to the number of active replication forks. To evaluate the relevance of this apparent surplus of Mcm2–7 complexes in huma...

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Bibliografski detalji
Glavni autori: Ibarra, Arkaitz, Schwob, Etienne, Méndez, Juan
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2449346/
https://ncbi.nlm.nih.gov/pubmed/18579778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803978105
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