TSC loss distorts DNA replication programme and sensitises cells to genotoxic stress

Tuberous Sclerosis (TSC) is characterized by exorbitant mTORC1 signalling and manifests as non-malignant, apoptosis-prone neoplasia. Previous reports have shown that TSC(-/-) cells are highly susceptible to mild, innocuous doses of genotoxic stress, which drive TSC(-/-) cells into apoptotic death. I...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Pai, Govind M., Zielinski, Alexandra, Koalick, Dennis, Ludwig, Kristin, Wang, Zhao-Qi, Borgmann, Kerstin, Pospiech, Helmut, Rubio, Ignacio
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2016
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5356742/
https://ncbi.nlm.nih.gov/pubmed/27863419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13378
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