Cdc45 is limiting for replication initiation in humans

Cdc45 is an essential protein that together with Mcm2-7 and GINS forms the eukaryotic replicative helicase CMG. Cdc45 seems to be rate limiting for the initial unwinding or firing of replication origins. In line with this view, Cdc45-overexpressing cells fired at least twice as many origins as contr...

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Bibliographic Details
Published in:Cell Cycle
Main Authors: Köhler, Carsten, Koalick, Dennis, Fabricius, Anja, Parplys, Ann Christin, Borgmann, Kerstin, Pospiech, Helmut, Grosse, Frank
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4889307/
https://ncbi.nlm.nih.gov/pubmed/26919204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1152424
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