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DNA binding properties of human Cdc45 suggest a function as molecular wedge for DNA unwinding
The cell division cycle protein 45 (Cdc45) represents an essential replication factor that, together with the Mcm2-7 complex and the four subunits of GINS, forms the replicative DNA helicase in eukaryotes. Recombinant human Cdc45 (hCdc45) was structurally characterized and its DNA-binding properties...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3936751/ https://ncbi.nlm.nih.gov/pubmed/24293646 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1217 |
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