DNA binding properties of human Cdc45 suggest a function as molecular wedge for DNA unwinding

The cell division cycle protein 45 (Cdc45) represents an essential replication factor that, together with the Mcm2-7 complex and the four subunits of GINS, forms the replicative DNA helicase in eukaryotes. Recombinant human Cdc45 (hCdc45) was structurally characterized and its DNA-binding properties...

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Hlavní autoři: Szambowska, Anna, Tessmer, Ingrid, Kursula, Petri, Usskilat, Christian, Prus, Piotr, Pospiech, Helmut, Grosse, Frank
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936751/
https://ncbi.nlm.nih.gov/pubmed/24293646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt1217
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