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Cdc45 is limiting for replication initiation in humans
Cdc45 is an essential protein that together with Mcm2-7 and GINS forms the eukaryotic replicative helicase CMG. Cdc45 seems to be rate limiting for the initial unwinding or firing of replication origins. In line with this view, Cdc45-overexpressing cells fired at least twice as many origins as contr...
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| Publié dans: | Cell Cycle |
|---|---|
| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Taylor & Francis
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4889307/ https://ncbi.nlm.nih.gov/pubmed/26919204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1152424 |
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