Φορτώνει......
The Discovery of a Reciprocal Relationship between Tyrosine-Kinase Signaling and Cullin Neddylation
While neddylation is known to activate cullin (CUL)-RING ubiquitin ligases (CRLs), its role in regulating T cell signaling is poorly understood. Using the investigational NEDD8 activating enzyme (NAE) inhibitor, MLN4924, we found that neddylation negatively regulates T cell receptor (TCR) signaling,...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Public Library of Science
2013
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3790728/ https://ncbi.nlm.nih.gov/pubmed/24124476 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075200 |
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