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Anticancer drug discovery by targeting cullin neddylation

Protein neddylation is a post-translational modification which transfers the ubiquitin-like protein NEDD8 to a lysine residue of the target substrate through a three-step enzymatic cascade. The best-known substrates of neddylation are cullin family proteins, which are the core component of Cullin–RI...

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Bibliografske podrobnosti
izdano v:Acta Pharm Sin B
Main Authors: Yu, Qing, Jiang, Yihan, Sun, Yi
Format: Artigo
Jezik:Inglês
Izdano: Elsevier 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7276695/
https://ncbi.nlm.nih.gov/pubmed/32528826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2019.09.005
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