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Targeting Protein Neddylation to Inactivate Cullin-RING Ligases by Gossypol: A Lucky Hit or a New Start?

Cullin-RING E3 ligases (CRLs) are the largest family of E3 ubiquitin ligases, responsible for about 20% of the protein degradation by the ubiquitin-proteasome system (UPS). Given their vital roles in multiple cellular processes, and over-activation in many human cancers, CRLs are validated as promis...

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Bibliografski detalji
Izdano u:Drug Des Devel Ther
Glavni autori: Yu, Qing, Sun, Yi
Format: Artigo
Jezik:Inglês
Izdano: Dove 2021
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7797302/
https://ncbi.nlm.nih.gov/pubmed/33442232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S286373
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