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Targeting Neddylation Pathways to Inactivate Cullin-RING Ligases for Anticancer Therapy
Significance: Protein neddylation is catalyzed by an E1 NEDD8-activating enzyme (NAE), an E2 NEDD8-conjugating enzyme, and an E3 NEDD8 ligase. Known physiological substrates of neddylation are cullin family members. Cullin neddylation leads to activation of cullin-RING ligases (CRLs), the largest fa...
Guardat en:
| Publicat a: | Antioxid Redox Signal |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Mary Ann Liebert, Inc.
2014
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4241876/ https://ncbi.nlm.nih.gov/pubmed/24410571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2013.5795 |
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