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Targeting Neddylation Pathways to Inactivate Cullin-RING Ligases for Anticancer Therapy
Significance: Protein neddylation is catalyzed by an E1 NEDD8-activating enzyme (NAE), an E2 NEDD8-conjugating enzyme, and an E3 NEDD8 ligase. Known physiological substrates of neddylation are cullin family members. Cullin neddylation leads to activation of cullin-RING ligases (CRLs), the largest fa...
Kaydedildi:
| Yayımlandı: | Antioxid Redox Signal |
|---|---|
| Asıl Yazarlar: | , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Mary Ann Liebert, Inc.
2014
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4241876/ https://ncbi.nlm.nih.gov/pubmed/24410571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2013.5795 |
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