The Discovery of a Reciprocal Relationship between Tyrosine-Kinase Signaling and Cullin Neddylation

While neddylation is known to activate cullin (CUL)-RING ubiquitin ligases (CRLs), its role in regulating T cell signaling is poorly understood. Using the investigational NEDD8 activating enzyme (NAE) inhibitor, MLN4924, we found that neddylation negatively regulates T cell receptor (TCR) signaling,...

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Main Authors: Friend, Samantha F., Peterson, Lisa K., Treacy, Eric, Stefanski, Adrianne L., Sosinowski, Tomasz, Pennock, Nathan D., Berger, Allison J., Winn, Virginia D., Dragone, Leonard L.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2013
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790728/
https://ncbi.nlm.nih.gov/pubmed/24124476
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075200
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