Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling

Here we report that ILK localizes in the mouse primary cilium, a sensory organelle required for signalling by the Hedgehog (Hh) pathway. Genetic or pharmacological inhibition of ILK blocks ciliary accumulation of the Hh pathway effector smoothened (Smo) and suppresses the induction of Gli transcript...

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Bibliografiska uppgifter
Huvudupphovsmän: Barakat, Badia, Yu, Liang, Lo, Camden, Vu, Duc, De Luca, Elisabetta, Cain, Jason E, Martellotto, Luciano G, Dedhar, Shoukat, Sadler, Anthony J, Wang, Die, Neil Watkins, D, Hannigan, Gregory E
Materialtyp: Artigo
Språk:Inglês
Publicerad: European Molecular Biology Organization 2013
Ämnen:
Scientific Reports
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790053/
https://ncbi.nlm.nih.gov/pubmed/23877428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2013.110
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