Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling

Here we report that ILK localizes in the mouse primary cilium, a sensory organelle required for signalling by the Hedgehog (Hh) pathway. Genetic or pharmacological inhibition of ILK blocks ciliary accumulation of the Hh pathway effector smoothened (Smo) and suppresses the induction of Gli transcript...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Barakat, Badia, Yu, Liang, Lo, Camden, Vu, Duc, De Luca, Elisabetta, Cain, Jason E, Martellotto, Luciano G, Dedhar, Shoukat, Sadler, Anthony J, Wang, Die, Neil Watkins, D, Hannigan, Gregory E
Format: Artigo
Sprache:Inglês
Veröffentlicht: European Molecular Biology Organization 2013
Schlagworte:
Scientific Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790053/
https://ncbi.nlm.nih.gov/pubmed/23877428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2013.110
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