Single-molecule imaging of Hedgehog pathway protein Smoothened in primary cilia reveals binding events regulated by Patched1

Accumulation of the signaling protein Smoothened (Smo) in the membrane of primary cilia is an essential step in Hedgehog (Hh) signal transduction, yet the molecular mechanisms of Smo movement and localization are poorly understood. Using ultrasensitive single-molecule tracking with high spatial/temp...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Milenkovic, Ljiljana, Weiss, Lucien E., Yoon, Joshua, Roth, Theodore L., Su, YouRong S., Sahl, Steffen J., Scott, Matthew P., Moerner, W. E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500289/
https://ncbi.nlm.nih.gov/pubmed/26100903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1510094112
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