Interaction of smoothened with integrin-linked kinase in primary cilia mediates Hedgehog signalling

Here we report that ILK localizes in the mouse primary cilium, a sensory organelle required for signalling by the Hedgehog (Hh) pathway. Genetic or pharmacological inhibition of ILK blocks ciliary accumulation of the Hh pathway effector smoothened (Smo) and suppresses the induction of Gli transcript...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Main Authors: Barakat, Badia, Yu, Liang, Lo, Camden, Vu, Duc, De Luca, Elisabetta, Cain, Jason E, Martellotto, Luciano G, Dedhar, Shoukat, Sadler, Anthony J, Wang, Die, Neil Watkins, D, Hannigan, Gregory E
Formáid: Artigo
Teanga:Inglês
Foilsithe: European Molecular Biology Organization 2013
Ábhair:
Scientific Reports
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790053/
https://ncbi.nlm.nih.gov/pubmed/23877428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2013.110
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla