Evaluation of NHS Carbamates as a Potent and Selective Class of Endocannabinoid Hydrolase Inhibitors

[Image: see text] Monoacylglycerol lipase (MAGL) is a principal metabolic enzyme responsible for hydrolyzing the endogenous cannabinoid (endocannabinoid) 2-arachidonoylglycerol (2-AG). Selective inhibitors of MAGL offer valuable probes to further understand the enzyme’s function in biological system...

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Detalhes bibliográficos
Main Authors: Niphakis, Micah J., Cognetta, Armand B., Chang, Jae Won, Buczynski, Matthew W., Parsons, Loren H., Byrne, Frederika, Burston, James J., Chapman, Victoria, Cravatt, Benjamin F.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778430/
https://ncbi.nlm.nih.gov/pubmed/23731016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn400116z
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