Remarkably selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates

The endocannabinoids 2-arachidonoyl glycerol (2-AG) and N-arachidonoyl ethanolamine (anandamide) are principally degraded by monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH), respectively. The recent discovery of O-aryl carbamates such as JZL184 as selective MAGL inhibitors has e...

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Autors principals: Chang, Jae Won, Niphakis, Micah J., Lum, Kenneth M., Cognetta, Armand B., Wang, Chu, Matthews, Megan L., Niessen, Sherry, Buczynski, Matthew W., Parsons, Loren H., Cravatt, Benjamin F.
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361572/
https://ncbi.nlm.nih.gov/pubmed/22542104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.03.009
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