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Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism
Monoacylglycerol lipase (MAGL) is a principal degradative enzyme for the endocannabinoid 2-arachidonoylglycerol (2-AG). We recently reported a piperidine carbamate, JZL184, that inhibits MAGL with high potency and selectivity. Here, we describe a comprehensive mechanistic characterization of JZL184....
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2867454/ https://ncbi.nlm.nih.gov/pubmed/19635411 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2009.05.009 |
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