Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

Prolonged exposure to drugs of abuse, such as cannabinoids and opioids, leads to pharmacological tolerance and receptor desensitization in the nervous system. Here we show that a similar form of functional antagonism is produced by sustained inactivation of monoacylglycerol lipase (MAGL), the princi...

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Detalhes bibliográficos
Main Authors: Schlosburg, Joel E., Blankman, Jacqueline L., Long, Jonathan Z., Nomura, Daniel K., Pan, Bin, Kinsey, Steven G., Nguyen, Peter T., Ramesh, Divya, Booker, Lamont, Burston, James J., Thomas, Elizabeth A., Selley, Dana E., Sim-Selley, Laura J., Liu, Qingsong, Lichtman, Aron H., Cravatt, Benjamin F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928870/
https://ncbi.nlm.nih.gov/pubmed/20729846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2616
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