Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

Prolonged exposure to drugs of abuse, such as cannabinoids and opioids, leads to pharmacological tolerance and receptor desensitization in the nervous system. Here we show that a similar form of functional antagonism is produced by sustained inactivation of monoacylglycerol lipase (MAGL), the princi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Schlosburg, Joel E., Blankman, Jacqueline L., Long, Jonathan Z., Nomura, Daniel K., Pan, Bin, Kinsey, Steven G., Nguyen, Peter T., Ramesh, Divya, Booker, Lamont, Burston, James J., Thomas, Elizabeth A., Selley, Dana E., Sim-Selley, Laura J., Liu, Qingsong, Lichtman, Aron H., Cravatt, Benjamin F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928870/
https://ncbi.nlm.nih.gov/pubmed/20729846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2616
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge