Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

Prolonged exposure to drugs of abuse, such as cannabinoids and opioids, leads to pharmacological tolerance and receptor desensitization in the nervous system. Here we show that a similar form of functional antagonism is produced by sustained inactivation of monoacylglycerol lipase (MAGL), the princi...

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Библиографические подробности
Главные авторы: Schlosburg, Joel E., Blankman, Jacqueline L., Long, Jonathan Z., Nomura, Daniel K., Pan, Bin, Kinsey, Steven G., Nguyen, Peter T., Ramesh, Divya, Booker, Lamont, Burston, James J., Thomas, Elizabeth A., Selley, Dana E., Sim-Selley, Laura J., Liu, Qingsong, Lichtman, Aron H., Cravatt, Benjamin F.
Формат: Artigo
Язык:Inglês
Опубликовано: 2010
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2928870/
https://ncbi.nlm.nih.gov/pubmed/20729846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2616
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