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Selective N-hydroxyhydantoin carbamate inhibitors of mammalian serine hydrolases

Serine hydrolase inhibitors, which facilitate enzyme function assignment and are used to treat a range of human disorders, often act by an irreversible mechanism that involves covalent modification of the serine hydrolase catalytic nucleophile. The portion of mammalian serine hydrolases for which se...

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Publicado en:Chem Biol
Autores principales: Cognetta, Armand B., Niphakis, Micah J., Lee, Hyeon-Cheol, Martini, Michael L., Hulce, Jonathan J., Cravatt, Benjamin F.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527528/
https://ncbi.nlm.nih.gov/pubmed/26120000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2015.05.018
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