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Remodeling Natural Products: Chemistry and Serine Hydrolase Activity of a Rocaglate-Derived β-Lactone

[Image: see text] Flavaglines are a class of natural products with potent insecticidal and anticancer activities. β-Lactones are a privileged structural motif found in both therapeutic agents and chemical probes. Herein, we report the synthesis, unexpected light-driven di-epimerization, and activity...

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Main Authors: Lajkiewicz, Neil J., Cognetta, Armand B., Niphakis, Micah J., Cravatt, Benjamin F., Porco, John A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Chemical Society 2014
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978386/
https://ncbi.nlm.nih.gov/pubmed/24447064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja412431g
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