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Combining cross-metathesis and activity-based protein profiling: New β-lactone motifs for targeting serine hydrolases
β-Lactones are a privileged structural motif as enzyme inhibitors and chemical probes, particularly for the inhibition of enzymes from the serine hydrolase class. Herein, we demonstrate that cross-metathesis (CM) of α-methylene-β-lactones offers rapid access to structurally diverse, previously unexp...
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| Publicat a: | Bioorg Med Chem Lett |
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| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2015
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4279111/ https://ncbi.nlm.nih.gov/pubmed/25541002 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.11.038 |
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