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O-Hydroxyacetamide Carbamates as a Highly Potent and Selective Class of Endocannabinoid Hydrolase Inhibitors

[Image: see text] The two major endocannabinoid transmitters, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), are degraded by distinct enzymes in the nervous system, fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL), respectively. FAAH and MAGL inhibitors cause elevations in b...

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Bibliografiske detaljer
Main Authors: Niphakis, Micah J., Johnson, Douglas S., Ballard, T. Eric, Stiff, Cory, Cravatt, Benjamin F.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2011
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3382460/
https://ncbi.nlm.nih.gov/pubmed/22860211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn200089j
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