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Characterization of tunable piperidine and piperazine carbamates as inhibitors of endocannabinoid hydrolases

Monoacylglycerol lipase (MAGL) and fatty acid amide hydrolase (FAAH) are two enzymes from the serine hydrolase superfamily that degrade the endocannabinoids 2-arachidonoylglycerol and anandamide, respectively. We have recently discovered that MAGL and FAAH are both inhibited by carbamates bearing an...

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Detalhes bibliográficos
Main Authors: Long, Jonathan Z., Jin, Xin, Adibekian, Alexander, Li, Weiwei, Cravatt, Benjamin F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2828288/
https://ncbi.nlm.nih.gov/pubmed/20099888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm9016976
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